Dystrophic calcification slideshare

Dystrophic Calcification Dystrophic calcification is encountered in areas of necrosis of any type. It is certain in the atheromas of advanced atherosclerosis, associated with intimal injury in the aorta and large arteries Although dystrophic calcification may be an incidental finding indicating insignificant past cell injury, it may also be a cause of organ dysfunction General dystrophic calcification of the oral regions Dystrophic calcification is the precipitation of calcium salts into primary sites of chronic inflamation or dead and dying tissue

DYSTROPHIC CALCIFICATION• Macroscopic deposition of Ca salts in dead or degenerated tissue(injured tissues).• It represents extracellular deposition of calcium from circulation or interstitial fluid. DYSTROPHICCALCIFICATION Dystrophic calcification is encountered in areas of necrosis of any type It is certain in atheromas of advanced atherosclerosis , associated with initial injury in the aorta and large arteries Although dystrophic calcification may be an incidental finding indicating in significant past cell injury , it may also be a cause of organ dysfunction For example-dystrophic calcification of aortic valve is an important cause of aortic stenosis in elderl

Soft tissue calcifications and ossifications - SlideShar

  1. Dystrophic calcification: Dystrophic calcification is characterised by deposition of calcium salts in dead and degenerated tissues with normal calcium metabolism and normal serum calcium levels. Pathogenesis: 2 Phases 1
  2. radiographic features of soft tissue calcification in orofacial regio
  3. Foci of ossification typically occurred adjacent to large vessels. Of the 27 cases showing calcification, coarse dystrophic calcification was seen in 22 cases, psammomatous calcification in nine cases, and combined dystrophic and psammomatous calcification was seen in four cases
  4. Dystrophic soft tissue calcification is a type of soft-tissue calcification, which occurs in damaged or necrotic tissue, while the serum level of calcium and phosphorus are normal. It may progress to ossification , in which case a cortical and trabecular bone pattern is visible
  5. Dystrophic pulp calcification. A common finding in the pulp in all age groups is the presence of dystrophic calcification or pulp stones. These are more common in teeth with diseased pulps but may also be found in unerupted teeth

Pathologic Calcification - SlideShar

  1. eralization of soft tissue without a systemic
  2. The two most commonly encountered types of calcification include: normal age-related intracranial calcifications; intracranial arterial atherosclerosis; Concerning calcifications are much less common and occur in a variety of settings, including 3. infection. neurocysticercosis; cerebral toxoplasmosis; TORCH infection; metabolic. hypoparathyroidis
  3. Dystrophic calcinosis cutis occurs in areas of tissue damage secondary to infection, inflammatory processes, connective tissue diseases, or cutaneous neoplasms . It is the most common form of ectopic calcification and develops around local tissue damage without any alteration to calcium or phosphate metabolism, for example, in AV
  4. The prevalence of dystrophic calcification ranged between 2.5% (on dental cysts) to 40.5% (on radicular cysts) . Only one study clearly reported the evaluation of this alteration on capsules of OC, while the other studies did not specify if dystrophic calcification was present in the epithelial lining, in the capsule, or both

Amyloidosis and pathological calcification - SlideShar

Soft tissue calcification orofacial region - SlideShar

  1. Dystrophic calcification, psammoma bodies, moderate-to-severe dystrophic calcification and hydrosalpinges were associated with positive C. trachomatis IgG titers. Conclusion This study suggests relationship of C. trachomatis with dystrophic calcification, psammoma bodies, adhesions, and hydrosalpinges
  2. Dystrophic calcification is defined as calcification in altered necrotic tissue resulting from an underlying inflammatory process. It occurs in patients whose serum calcium and phosphorus levels are normal . Iatrogenic calcification results from a previous procedure or treatment such as repeated injections
  3. ogen consumption) result in insufficient local plas
  4. Soft-tissue calcifications are commonly divided into dystrophic, metastasis, idiopathic, and iatrogenic according to the etiology. Dystrophic calcification is the most common cause of soft-tissue calcification, caused by tumors, trauma, parasitic infestations, autoimmune disorders, injection sites, and burn. 1, 2 The prevalence of severe calcification in the overall population of patients with.
  5. Soft tissue calcification (mnemonic) Dr Daniel J Bell and Dr Mohammad Taghi Niknejad et al. Mnemonics to remember the causes of soft tissue calcification include: My GHOSTS 1. TIC MTV 2
  6. Introduction. Dystrophic calcification of the small intestine is a rare finding encountered during radiographic evaluation of the abdomen. Such calcification is commonly associated with intestinal schistosomal infection or small intestinal neoplasms ().Less commonly, chronic renal failure may lead to ectopic calcification at many different sites in the body, including the small intestine ()
  7. Metastatic pulmonary calcification is an unfortunate term in that metastatic suggests a malignant process, but in fact purely refers to the spread to and deposition of the excess calcium in the lungs. In truth, malignancy is only very rarely the etiology. The calcification refers to a cellular pathological process, and it is not unusual to.

Calcification and ossification in conventional schwannoma

Dystrophic calcification of necrotic myocardium has been observed in some gene-targeted mouse models of cardiomyopathy 23-25: in mice with inactivation of desmin, the authors reported strong Opn expression in co-localization with calcified myocardial necrosis, yet function and regulation of Opn were not elucidated further. 25 Certain. Change in size and shape of bone. Change in number and orientation of trabeculae. Altered thickness, density of cortical structures. General changes in bone w. systemic diseases. In developing teeth, there is: - Accelerated or delayed eruption. - Hypoplasia, hypo calcification radiology Ossification calcification

Soft tissue calcification in the neck observed in cone beam CT scan

Dystrophic soft tissue calcification Radiology Reference

Calcification is a word pathologists use when calcium builds up inside of a tissue sample. When examined under a microscope areas of calcification look much darker than the surrounding normal tissue. Calcifications can be seen on routine H&E stained slides. Pathologists can also perform a special stain called a von Kossa stain to see calcium. Pathological calcification is defined as ectopic calcification in which calcium phosphate deposits form in soft tissues 1,2.Soft tissue calcification occurs in many pathological processes. Chronic Venous Insufficiency and Dystrophic Subcutaneous Calcification. List of authors. David Miedinger, M.D., and Thomas Daikeler, M.D. February 28, 2008. N Engl J Med 2008; 358:e10. DOI: 10. Calcification within lung cancer occurs by the following mechanisms: (A) calcified scars or granuloma engulfed by a tumor, (B) dystrophic calcification in the necrotic parts of tumor, and (C) calcium deposition by the secretory function of carcinoma itself (e.g., mucinous adenocarcinoma) as in our case (1, 9)

Pulp Stones - an overview ScienceDirect Topic

  1. (b) Axial non-contrast CT image of right shoulder. Fig. 7. Excised lesion, third web space left hand. Unstained pathology Fig. 5. Plain radiograph showing periarticular calcification over right fifth slide showing hyalinized fibroconnective tissue, multiple cystic spaces toe. displaying dystrophic calcification and calcospherites
  2. Calcification without bone formation — Pathological soft tissue calcification without bone formation can be divided into two broad categories, metastatic and dystrophic calcifications, and the rare disorder pulmonary alveolar microlithiasis : Metastatic calcification is defined by calcium salt deposition in normal tissues
  3. Ectopic calcification is divided into dystrophic calcification and metastatic calcification. Dystrophic calcification is caused by tissue necrosis while metastatic calcification is induced by the metabolic disorder of calcium and phosphorus. Tissue sections were deparaffinized and rehydrated by passing the slides through xylene (3 washes.
  4. The slight calcification observed in the lungs might have been dystrophic, associated with the inflammatory process in the pulmonary tissue. However, no plausible explanation could be found for the widespread metastatic calcification observed in all other organs

Calcification and ossification are uncommon in schwannomas; however, when present these findings may cause diagnostic confusion with other mesenchymal tumors which more frequently harbor these features. We sought to better characterize the type and rate of calcification and ossification in schwannomas. Cases of schwannoma diagnosed at our institution from 2005 to 2019 were reviewed to. Results: Four patterns of microcalcifications were noted in association with prostate cancer: (1) dystrophic calcification in the comedo-type necrosis of Gleason pattern 5, (2) intraluminal calcification in cribriform-type Gleason pattern 3 prostate cancer, (3) intraluminal calcification in small acinar adenocarcinoma, and (4) stromal. Calcification of the skin occurs in four main forms namely dystrophic, metastatic, iatrogenic and idiopathic. Idiopathic calcinosis cutis of the penis is exceedingly rare as only five cases have been reported till date to the best of our knowledge. Herein, we present another case of this rare entity in a 29-year old man and discuss its probable. Myositis ossificans (MO) is the most common form of heterotopic ossification usually within large muscles. Its importance stems in large part from its ability to mimic more aggressive pathological processes. Myositis ossificans is one of the skeletal don't touch lesions.. There are some conditions that are related to, or share a similar name to, myositis ossificans 1 Objective To correlate Chlamydia trachomatis immunoglobulin gamma (IgG) titers with psammoma bodies, dystrophic peritoneal calcification, degree of calcification, adhesions, and hydrosalpinges.Design This is a prospective single-blinded histologic analysis of tissue and retrospective analysis of historical laboratory and clinical variables

The aim of this study was (i) to determine the frequency of nephrocalcinosis (excluding oxalosis and dystrophic calcification of necrosis) in autopsies and renal biopsies and (ii) to elucidate whether the etiology of nephrocalcinosis was associated with a special morphological pattern, including appearance, distribution and density of. Kossa staining is specific for calcification. Calcium deposits become yellowish-brownish with this stain. This calcification is a type of dystrophic calcification (in contrast to metastatic calcification), meaning that it associated with necrosis and not with the calcium level in the blood SLIDE 8: Liver, fatty SLIDE 9: Liver, normal Fatty Liver increased weight, yellow color Pathogenesis: The process has Two major phases Initiation intracellular starts in mitochondria of dead cells extracellular phospholipids in membrane vesicles from degenerating cells 2) Propagation ** Hyperparathroidism increase bone resorption increase Ca. The primary mechanism for metastatic calcification is deranged calcium metabolism. This is a system increase in calcium, with increase in serum calcium. The primary mechanism for dystrophic calcification is tissue injury. This is a local increase in calcium, without an increase in serum calcium. Slide P15 . Organ: Coronary arter Dystrophic calcification is seen in these cases: Tuberculosis Caseous necrosis is a common area for dystrophic calcification; Atherosclerosis The calcification that takes place in AS is dystrophic. Heart valve disease. Aging or damaged valves will become calcified, which severely reduces its motion and causes stenosis. Adiponecrosis; Cancer cell

Dystrophic calcification - wikido

Multiple intracranial calcifications Radiology Reference

Calcifying Acne: An Unusual Extraoral Radiographic Findin

The mineral in physiologically calcified vertebrate tissues is an analog of the geologic mineral, hydroxyapatite (Fig. 1).The physiologic hydroxyapatite crystals are much smaller than those found in geologic deposits and have stoichiometries different from the predicted 10Ca:6PO 4:2OH of the geologic mineral.For that reason biologic vertebrate mineral is often referred to as apatite or. Figure 1: Lymph node calcification, Lungs. In Figure 2, you can see a calcified lymph node in the armpit. Figure 2: Calcified Lymph Node, Armpit/Axillary. Calcium builds up in the lymph nodes over time due to infections. In the lungs, this is usually caused by either tuberculosis or histoplasmosis (a fungal infection) Mönckeberg's arteriosclerosis, or Mönckeberg's sclerosis, is a form of arteriosclerosis or vessel hardening, where calcium deposits are found in the muscular middle layer of the walls of arteries (the tunica media). It is an example of dystrophic calcification.This condition occurs as an age-related degenerative process. However, it can occur in pseudoxanthoma elasticum and idiopathic.

While dystrophic calcification is defined as amorphous deposits of calcium phosphate in damaged soft tissues, heterotopic ossification is the formation of mature, mineralized bone tissue Although the histopathology of dystrophic calcification and heterotopic ossification are well described, the molecular mechanisms that lead to their. Psammomma bodies: they are concentric laminations of calcification. This is an example of dystrophic calcification. We all know that dystrophic calcification occurs in dead and degenerated tissue. In this case, the calcification occurs due to death of tumor cells, particularly at the tips of the papillae Comments: Cross section demonstrating a broad-based tumor attached to the dura.This particular meningioma has a coarse granular tan-white appearance that may feel gritty when cut, particularly if it is rich in Psammoma bodies (a form of dystrophic calcification seen microscopically as concentric lamellated calcified structures). Meningiomas make up 20% to 30% of intracranial tumors and show. Calcification is occasionally observed in tumors, regardless of the organ or type of tumor. It is a notable radiologic feature and one that potentially has clinical significance, since the identification of intratumoral calcification facilitates detection of the tumor as well as its differential diagnosis (1, 2).In the abdominopelvic cavity, various kinds of tumors such as, for instance, mucin. INTRODUCTION. Vascular calcification is a common phenomenon in the elderly, predominantly occurring in the basal ganglia and in the lamina circumvoluta medullaris of the hippocampus. 1 They have to be distinguished from Fahr's disease. 2 Calcification is not an inherent feature of Alzheimer's disease. On the other hand, a rare presenile type of dementia with symmetrical Fahr-type.

André Jaggy (ed.) Small Animal Neurology An Illustrated Text This page intentionally left blank André Jaggy (ed.) Small Animal Neurology An Illustrated Text Associate editor Simon R. Platt English translation Teresa J. Gatesma Die SlideShare-Präsentation wird heruntergeladen. • Dystrophic calcification • Metastatic calcification Dystrophic calcification :characterized by deposition of salts in dead or degenerated tissues with normal calcium metabolism and normal serum calcium levels. Metastatic calcification: Occurs in normal tissues and is associated with. Dystrophic valve calcification. Hematoxylin-eosin Fibrinous pericarditis. Hematoxylin-eosin Fatty heart. Hematoxylin-eosin Stenosing atherosclerosis of heart arteries. Hematoxylin-eosin Occlusive arterial thrombosis. Hematoxylin-eosin Respiratory system Destructive desquamative tracheitis. Severe form of flu. Hematoxylin-eosi Metastatic calcification can occur in tissues which do not normally mineralise when the circulating levels of Ca+2 and/or PO4-3 are increased (e.g. parathyroid tumour) 2. Dystrophic calcification occurs with normal levels of calcium/phosphate where nuclei facilitate precipitation - these include necrotic and injured tissue 3

Dystrophic calcification and respiratory metaplasia in the

Dystrophic calcification can be further divided into either localized (calcinosis circumscripta) or widespread (calcinosis universalis, calcinosis cutis). Apocrine sweat gland cysts, follicular cysts, and skin tumors have been associated with calcinosis circumscripta ( Wachtman et al. 2006 ), while hyperadrenocorticism and diabetes mellitus. the calcified nodules. Dystrophic calcification can be further divided into either localized (calcinosis circumscripta) or widespread (calcinosis universalis, calcinosis cutis). Apocrine sweat gland cysts, follicular cysts, and skin tumors have been associated with cal-cinosis circumscripta (Wachtman et al. 2006), while hypera ORIGINAL ARTICLE JJBMR Plasmin Prevents Dystrophic Calcification After Muscle Injury 1 1,2 3 1,4 3 Nicholas A Mignemi, Masato Yuasa, Courtney E Baker, Stephanie N Moore, Rivka C Ihejirika, 1 3 2 2 5 William K Oelsner, Christopher S Wallace, Toshitaka Yoshii, Atsushi Okawa, Alexey S Revenko, 5 5 3,4 1 6 A Robert MacLeod, Gourab Bhattacharjee, Joey V Barnett, Herbert S Schwartz, Jay L Degen, 6.

Calcific tendonitis of the quadriceps tendon Journal of

Dystrophic calcification (DC) is the abnormal appearance of calcified deposits in degenerating tissue, often associated with injury. R&D Systems, Minneapolis, Minnesota, USA) was used to detect the presence of MDSCs. The slides were mounted with 4′,6-diamidino-2-phenylindole (DAPI)-containing mounting medium (Vector Laboratories), and. ABSTRACT : Five cases of calcified urinary bladder tumors have been noted in 75 cases examined. Three types of calcifications were seen: (1) hazy opacity with a dense rim; (2) speckled irregular or serpiginous stippling; and (3) nodular, coarse calcification · Pathologic calcification occurs in two forms: · Dystrophic: Occurs in normocalcemic animals, often in areas of necrosis · Metastatic: Occurs in hypercalcemic animals with a predilection for tissues that have an internal alkaline compartment (gastric mucosa, kidneys, lungs, systemic arteries, and pulmonary veins

Hyalinizing variant: dense paucicellular hyalinizing fibrosis effacing ≥ 80% of normal histologic structures, resulting in a thinned gallbladder wall with (porcelain gallbladder) or without dystrophic calcification Increased frequency of associated carcinoma (Sultan Qaboos Univ Med J 2016;16:e416, Am J Surg Pathol 2011;35:1104 Differential diagnosis. Metastatic calcification: due to hyperparathyroidism or chronic renal failure. Dystrophic calcinosis cutis: deposits in areas of previously abnormal skin. Tumoral calcinosis: no known cause. Idiopathic calcinosis of scrotum. Subepidermal calcified nodule: childhood papule, small, fleshy, firm, on face <p>Dystrophic calcinosis occurs in dermatomyositis and is more common in the juvenile form than in this classic (adult) form. This radiograph shows a 78-year-old female with dermatomyositis and extensive calcification of lobular morphology projecting over the majority of the pelvis.</p> Nonspecific calcification is seen in 1/3 rd of cases. It is frequently mistaken as benign pathology due to small size (<5 cm), slow indolent growth (average time to diagnosis 2-4 years, nonaggressive bony erosion), calcification, and well-defined lobulated outline. Imaging is not pathognomonic, but suggestive of the diagnosis There were statistically significant differences for dystrophic calcification, eosinophilic tumor cell changes, elastotic stromal/vascular change, islet cell hyperplasia, and nerve hypertrophy between the two groups, with these features seen more frequently in NAT cases

Pathologic Calcification

Calcium deposits in the skin often seem to occur without warning. These bumps might be a sign or symptom of a medical condition. The primary symptom of calcinosis is the appearance of firm, pimple. RT-qPCR revealed increases in osteogenic calcification transcripts in both Transwell and, more profoundly, direct coculture as compared to monoculture (Fig 4C - E). There was no change in dystrophic calcification markers (Fig 4F - H). AVIC-specific expression was confirmed by immunofluorescent staining for CD68 (macrophages) and RUNX2 (Fig 4I)

Dystrophic Metastatic. Pathologic Calcification Two types ___ calcification ___ calcification. Dystrophic Metastatic. Pathologic Calcification ___ calcification very common, calcium deposited in damaged or dying tissue serum calcium levels normal seen frequently in heart valves of elderly ___ calcification tuberculosis.15,16 Nodal calcification associated with infection is usually dystrophic in nature and related to necrosis.15 Calcified lymph nodes are a type of dystrophic calcification that occurs in lymph nodes in the healing process following various diseases.4,15 Pybus8 stated, if the primary focus was remove

Vascular calcification is associated with metabolic syndrome, diabetes, hypertension, atherosclerosis, chronic kidney disease, and end stage renal disease. Each of the above contributes to an accelerated and premature demise primarily due to cardiovascular disease. The above conditions are associated with multiple metabolic toxicities resulting in an increase in reactive oxygen species to the. Dystrophic calcification has two major phases: initiation (nucleation) and propagation, which can occur intracellularly or extracellularly. In the initiation phase, dead and dying cells can no longer regulate the influx of calcium into the cytosol, and calcium accumulates in the mitochondria Pathologic Calcification • Dystrophic Calcification - occurs in areas of necrosis and atherosclerosis. • Metastatic Calcification - occurs in normal tissues when there is hypercalcemia. implies there is damage of underlying organ. implies increased levels of circulating calciu

Goljan Pathology Slides 92598259 goljan systemic pathology notes slideshare, goljan patho slides usmle step aorta has only 2 valves doing the job of three and gets damaged leading to dystrophic calcification which narrows orifice of valve leading to aortic stenosis b metastatic calcification in cases o Other injuries, such as freeze-thaw injury directed to the myocardium, are reported to induce dystrophic cardiac calcification in a few rodent strains . On the basis of prior reports, we selected two murine models and their background wild-type (WT) strain (C57B6) for further investigation of the properties of the dystrophic deposits—OPN. Metastatic pulmonary calcification is an unfortunate term in that metastatic suggests a malignant process, but in fact purely refers to the spread to and deposition of the excess calcium in the lungs. In truth, malignancy is only very rarely the etiology. The calcification refers to a cellular pathological process, and it is not unusual to. Dystrophic calcinosis is the most common subtype of calcinosis cutis which is characterized by normal calcium and phosphate levels in serum 1. Dystrophic calcification appears as a result of local tissue damage and is most frequently observed in underlying autoimmune connective tissue disease (ACTD)


FIGURE 6.27. Solid renal cancer with dystrophic calcification. A contrast-enhanced axial CT image in a patient with a renal cancer demonstrates extensive dystrophic calcification within a minimally heterogeneous solid renal mass. Although some of the calcification is peripheral, some components are quite thick The transitional cells have pale eosinophilic or clear cytoplasm, uniform round or ovoid nuclei which may have grooves, fine chromatin, and punctate nucleoli. There is no cytologic atypia and mitotic activity is not increased. The stromal component resembles ovarian fibroma or thecoma. It may become hyalinized or show dystrophic calcification

Cell injuryadaptation 5

Calcifications can disrupt organ function in the cardiovascular system and the kidney, and are particularly common in patients with chronic kidney disease (CKD). Fetuin-A deficient mice maintained against the genetic background DBA/2 exhibit particularly severe soft tissue calcifications, while fetuin-A deficient C57BL/6 mice remain healthy. We employed molecular genetic analysis to identify. Calcinosis & Esophageal-motility-disorder & Soft-tissue-calcification Symptom Checker: Possible causes include Diffuse Cutaneous Systemic Scleroderma. Check the full list of possible causes and conditions now! Talk to our Chatbot to narrow down your search Dystrophic Calcification Abnormal calcification in which there is Normal blood calcium level + diseased or necrotic tissue. 1. Necrotic tissue - fat, coagulative, liquefactive, caseous necrosis 2. Atherosclerosis - Central necrotic core 3. Cells.Psammoma bodies 4. Damaged or aging heart valve Odontogenic / Jaw Cysts. Note: Odontogenic cysts are largely classified based on their location, viability of the associated tooth and clinical setting. The principal exception to this is the odontogenic keratocyst, which can occur in any site or setting. Unlike most of the other cysts, it has aggressive potential